Interurban Clinical Club

williamExcerpt from “The Interurban Clinical Club (1905-1994): A Record of Achievement in Clinical Science” by A. McGehee Harvey, M.D.; Sc.D. (Hon.) “William Osler founded the Interurban Clinical Club in 1905 for the purpose of exchanging ideas and fellowship among medical teachers in some of the leading Eastern medical schools. Since then, twice a year (with a few exceptions during World War II), one and one-half day meetings have been held in rotation first in Baltimore, New York, Boston and Philadelphia. A few years after the organization of the Club, members from New Haven were added. The five to nine active members from each city are chosen from the departments of medicine, pediatrics, neurology and psychiatry at the university medical schools of JohnsHopkins, Maryland, Pennsylvania, Temple, Jefferson, Columbia, Cornell, New York, Yale, Harvard, Tufts, Boston, Einstein, Downstate (Long Island) and from the Rockefeller Institute (later University). Many emeritus members (those members who have reached the age of 55 and those who have moved away from the five cities) join the active members in participating in the meetings.”

“Osler recognized that such a club organized for internists would be a way to advance medicine in America in a unique way…Everyone invited received a note as follows: ‘It is proposed to start among a few of the younger men in the Eastern cities an Interurban Club on lines somewhat similar to the Society of Clinical Surgery. The number of members will be limited. The objects of the Club will be: (1) to stimulate the study of internal medicine, (2) by mutual intercourse and discussion to improve our methods of work and teaching, (3) to promote the scientific investigation of disease, (4) to increase our knowledge of the methods of work in other clinics than our own. It is proposed to meet twice a year to have demonstrations and discussions but not set papers. The program of each meeting is to be supplied by the men in the city in which the meeting is being held…’”


211th Meeting on April 10, 2015 in New Haven
212th Meeting on November 6, 2015 in Boston
213th Meeting on April 1, 2016 in New York
214th Meeting on November 4, 2016 in Philadelphia
215th Meeting on April 7, 2017 in Baltimore
216th Meeting on November 3, 2017 in New Haven
217th Meeting on April 6, 2018 in Boston
218th Meeting on November 2, 2018 in New York


The Interurban Clinical Club congratulates and welcomes newly elected members:

210th Meeting on November 7, 2014 in Baltimore:
Zoltan P. Arany (Philadelphia), Renier Brentjens (New York), and Massimo Cristofanilli (Philadelphia)

209th Meeting on April 4, 2014 in Philadelphia:
Anne Coppola (Philadelphia), Tom Coppola (Philadelphia), Barbara Kazmierczak (New Haven), Calum MacRae (Boston), Barbara Murphy (New York), Maria New (New York; Honorary), Martin Pollak (Boston), Martin Pomper (Baltimore), and Jonathan Powell (Baltimore)

208th Meeting on November 1, 2013 in New York:
No newly elected members

207th Meeting on April 5, 2013 in Boston:
Elizabeth Jonas (New Haven), Ross Levine (New York), and Tomer Yaron (New York)

206th Meeting on October 26, 2012 in New Haven:
Daniel Goldstein (New Haven) and Bruce Levy (Boston)

205th Meeting on March 30, 2012 in Baltimore:
David E. Cohen (Boston)

204th Meeting on October 28, 2011 in Philadelphia:
Alfred G. Knudson, Jr. (Philadelphia; Honorary), and Timothy Wang (New York)

203rd Meeting on April 1, 2011 in New York:
Arturo Casadevall (New York), Landon S. King (Baltimore), Cloe Thio (Baltimore) and Victor Velculescu (Baltimore)

202nd Meeting on November 5, 2010 in Boston:
Linda Chin (Boston), Marie Egan (New Haven), Elizabeth Carson Engle (Boston), Kevan Herold (New Haven), Laurence Turka (Boston) and Jing Zhou (Boston)


211th Meeting of the Interurban Clinical Club
Yale University School of Medicine
Medical Historical Library
333 Cedar Street
New Haven, CT 06520
Friday, April 10, 2015

8:00 amContinental Breakfast Medical Historical Library, Yale University

9:00 amWelcoming Remarks and Opening
Elizabeth Jonas, M.D., Associate Professor of Medicine and of Neurobiology, Yale School of Medicine

9:15 am“Integrin-induced Effects on RNA Stability in Angiogenesis and Neuroinflammation” Jeffrey R. Bender, M.D., Robert I. Levy Professor of Cardiology and of Immunobiology, Director, Cardiovascular Research Center, Associate Chief, Cardiovascular Medicine, Yale School of Medicine

9:45 am“Energy Sensor and Cell Survival in the Heart” Lawrence Young, M.D., Professor of Medicine (Cardiology) and of Cellular and Molecular Physiology, Vice-Chairman, Department of Medicine, Yale School of Medicine

10:15 amSir William Osler Young Investigator Award
“Molecular Mechanisms of MDS and the Development of a Xenotransplantation Model” Stephanie Halene, M.D., Assistant Professor (Hematology), Department of Internal Medicine and Yale Cancer Center, Yale School of Medicine

10:45 -11:00 am Break

11:00 am“The Glycolytic Metabolon Meets Local Energy Demands In Vivo at Neuronal Synapses” Daniel Alfonso Colón-Ramos, Ph.D., Associate Professor of Cell Biology, Yale School of Medicine

11:30 am“Getting Calcium into Milk: Unexpected Lessons for Breast Cancer” John J. Wysolmerski, M.D., Professor of Medicine (Endocrinology), Yale School of Medicine

12:00 am“Innate Immune Recognition of Pathogens: From Mice to Men” Barbara I. Kazmierczak Ph.D., M.D., Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis, Director, MD-PhD Program, Yale School of Medicine

12:30 am“Child Abuse and Epigenetic Mechanisms of Disease Risk” Joan Kaufman, Ph.D., Associate Professor of Psychiatry
Director, Child and Adolescent Research and Education (CARE) Program Director, Child Welfare Unit, Zigler Center for Child Development and Social Policy

1:00 pmLunch (Members Only), Giarman Room, Yale School of Medicine, 333 Cedar Street

Lunch Speaker
“Academic Health Centers 2015” Robert J. Alpern, M.D., Ensign Professor of Medicine (Nephrology), Dean, Yale School of Medicine

2:00 pmTour of Yale Historical Library Collection

3:00 pm“Extended Release Guanfacine (Intuniv™) For the Treatment of Higher Cognitive Disorders: Successful Translation from Monkey to Man” Amy F. T. Arnsten, Ph.D., Professor of Neurobiology and of Psychology; Member, Kavli Institute of Neuroscience, Yale University

3:30 pmM.D.-Ph.D. Student Talks
“Genes and Mechanisms of Congenital Heart Disease: Converging Pathways in Developmental Disorders”. Samir Zaidi, YMG Class of 2016

3:45 pmM.D.-Ph.D. Student Talks
“Characterizing the Genomic Architecture and Molecular Mechanisms Driving the Formation of Non-NF2 Meningiomas” Victoria E. Clark, YMG Class of 2016

4:00 pmBusiness Meeting (Members Only)

6:30 pmCocktail Reception and Black Tie Dinner, The Union League Cafe, 1032 Chapel Street, New Haven, CT 06510

8:00 pm“William Osler and Arthur Conan Doyle: Partners in Detection” Thomas Duffy, M.D., Professor Emeritus, Yale School of Medicine

9:00 pmConclusion


210th Meeting of the Interurban Clinical Club
Johns Hopkins University School of Medicine
Owens Auditorium
Koch Cancer Research Building
1550 Orleans Street, Baltimore, MD 21287-0014
Friday, November 7, 2014

8.00 amContinental Breakfast Koch Cancer Research Building, Owens Auditorium

9.00 amWelcoming Remarks and Opening
Landon S. King, M.D., Executive Vice Dean, Professor of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine

9.15 am“Insights from Human Enteroids in Understanding Intestinal Physiology and Host-Pathogen Interactions” Mark Donowitz, M.D., LeBoff Professor of Medicine, Johns Hopkins University School of Medicine

9.45 am“Liquid Biopsy Approaches for Detecting and Characterizing Human Cancer” Victor Velculescu, M.D., Ph.D., Professor, Department of Oncology, Johns Hopkins University School of Medicine

10:15 -10:30 am Break

10:30 am“Kabuki syndrome: A Potentially Treatable Cause of Intellectual Disability.” Sir William Osler Young Investigator Award. Hans T. Bjornsson, M.D., Ph.D., Assistant Professor in Pediatrics and Genetics, Johns Hopkins University School of Medicine

11.00 am“Found in Translation: New Insights into the Pathogenesis and Treatment of Aortic Aneurysm” Hal Dietz, Ph.D., Victor A. McKusick Professor of Genetics in the Departments of Medicine, Pediatrics, and Molecular Biology and Genetics, Johns Hopkins University School of Medicine

11.30 am“Applications of Engineering Principles in Cancer Research” Denis Wirtz, Ph.D., Vice Provost for Research, TH Smoot Professor, Chemical and Biomolecular Engineering, Pathology, Oncology, Johns Hopkins University and Johns Hopkins School of Medicine

12:00 12:45 pmLunch in Koch Cancer Research Building, Owens Auditorium (Members Only)

12:45-1:30 pmTour of Hopkins Hospital Dome, 601 North Broadway, Baltimore, MD 21205

1:30 pm“Rebuilding Bodies: Regenerative Medicine From The Lab to The Clinic” Jennifer Elisseeff, Ph.D., Professor, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University School of Medicine

2:00 pm“Can Cancer Trigger Autoimmunity? Clues from systemic sclerosis” Erika Darrah, Ph.D., Assistant Professor, Department of Medicine, Johns Hopkins University School of Medicine

2:30 pmBreak

3:00 pm“A Serendipitous Finding leading to a Potentially Novel Treatment for Obesity and Type II Diabetes” Jonathan Powell, Ph.D.,
Professor, Department of Oncology, Johns Hopkins University School of Medicine

3:30 pm“Wireless Microrobots Perform Thousands of Biopsies In Vivo” Florin Selaru, M.D., Assistant Professor of Medicine and Oncology, Johns Hopkins University School of Medicine

4:00 pmBusiness Meeting (Members Only)

6:30 pmCocktail Reception and Black Tie Dinner, The Walters Art Museum, 600 N. Charles Street, Baltimore, MD 21201

8:00 pm“From Smallpox to Ebola: Responding to Biological Threats” D.A. Henderson, M.D., M.P.H., Dean Emeritus, Bloomberg School of Public Health, Johns Hopkins University

9:00 pmConclusion

209th Meeting of the Interurban Clinical Club
Smilow Center for Translational Research
University of Pennsylvania
3400 Civic Center Blvd., Philadelphia, PA 19104
Room 9-146
Friday, April 4, 2014

8.15 amContinental Breakfast Smilow Center Conference Lobby, Room 9-146

9.15 amWelcoming Remarks and Opening
Charles Abrams, M.D. Director, PENN-CHOP Blood Center for Patient Care & Discovery Associate Chief, Division of Hematology-Oncology University of Pennsylvania

Jonathan A. Epstein, MD William Wikoff Smith Professor of Medicine Chair, Department of Cell and Developmental Biology Scientific Director, Penn Cardiovascular Institute University of Pennsylvania

9.30 am“Stalking the wards for blood disease as a pediatric physician scientist” Mitchell J. Weiss, M.D., Ph.D., Jane Fishman Grinberg Professor of Pediatrics The Children’s Hospital of Philadelphia

10.00 am “The BRCA Tumor Suppressor Network” Roger A. Greenberg, M.D., Ph.D., Abramson Family Cancer Research Institute, University of Pennsylvania

10:30 -10:45 am Break

10:45 am “Using genetics to uncover novel antiviral targets” Sara Cherry, Ph.D., Associate Professor, Department of Microbiology, University of Pennsylvania

11:15 am“Targeting macrophages for cancer immunotherapy” Sir William Osler Young Investigator Award, Gregory L. Beatty, M.D., Ph.D., Assistant Professor, Division of Hematology-Oncology, University of Pennsylvania

12:00 12:45 pmLunch in Smilow Center for Translational Medicine Conference Room 9-100 (Members Only) “Opportunities for treatment of cancer through cancer cell-autonomous And non-autonomous mechanisms” D. Gary Gilliland, M.D., Ph.D., Vice Dean & Vice President, Precision Medicine

12:45-1:45 pmGuided Tour, University of Pennsylvania Museum of Archaeology & Anthropology, 3260 South Street, Philadelphia PA

1:45 pm“Reactivation of developmentally silenced globin genes by forced chromatin looping” Gerd A. Blobel, M.D., Ph.D., Frank E. Weise III Endowed Chair of Pediatrics, The Children’s Hospital of Philadelphia

2:15 pm“New insights into mammalian physiology from lymphatics”, Mark L. Kahn, M.D., B.A., Professor of Medicine, Penn Cardiovascular Institute, University of Pennsylvania

2:45 pm“Hematopoietic stem cell formation – lessons from the embryo” Nancy Speck, Ph.D., Professor of Cell and Developmental Biology, Cancer Biology, University of Pennsylvania

3:15 pmBreak

3:30 pm “The development and function of brown and beige adipocytes” Patrick Seale, Ph.D., Assistant Professor of Cell and Developmental Biology, University of Pennsylvania

4:00 pm“New biology and therapeutic targets inspired by human genetics” Daniel J. Rader, M.D., Chief, Division of Translational Medicine and Human Genetics, Director, Preventive Cardiovascular Medicine and Lipid Clinic, Director, Clinical and Translational Research Center, Associate Director, Institute for Translational Medicine and Therapeutics, Director, Cardiovascular Metabolism Unit, Institute for Diabetes, Obesity, & Metabolism, University of Pennsylvania

4:45 pmBusiness Meeting (Members Only)

6:00 pm Cocktail Reception and Black Tie Dinner, The Physick House, 321 S. 4th Street, Philadelphia, PA 19106

8:00 pm “Megatrends: Predictions for the Future of the American Health Care System” Ezekiel J. Emanuel, M.D., Ph.D., Vice Provost for Global Initiatives, Chair, Medical Ethics and Health Policy, University of Pennsylvania

9:00 pmConclusion